Publications

Asterisk indicates co-first authorship.


Injury Activates Transient Olfactory Stem Cell States With Diverse Lineage Capacities

Cell Stem Cell, December 2017

Manuscript in press. Details forthcoming. Read more

Levi Gadye*, Diya Das*, Michael A. Sanchez*, Kelly Street, Davide Risso, Ariane Baudhuin, Michael B. Cole, Allon Wagner, Yoon Gi Choi, Elizabeth Purdom, Sandrine Dudoit, Nir Yosef, John Ngai, and Russell B. Fletcher*. (2017). Injury Activates Transient Olfactory Stem Cell States With Diverse Lineage Capacities. Cell Stem Cell, in press.


Deconstructing Olfactory Stem Cell Trajectories at Single Cell Resolution

Cell Stem Cell, June 2017

The olfactory epithelium is a site of active neurogenesis. We combine single-cell transcriptomics and clonal lineage analysis to trace cell fates from the multipotent olfactory stem cell and identify multiple mechanisms controlling cell fate, including direct conversion of quiescent stem cells into support cells without cell division. Read more

Russell B. Fletcher*, Diya Das*, Levi Gadye, Kelly N. Street, Ariane Baudhuin, Allon Wagner, Michael B. Cole, Quetzal Flores, Yoon Gi Choi, Nir Yosef, Elizabeth Purdom, Sandrine Dudoit, Davide Risso and John Ngai. (2017). Deconstructing Olfactory Stem Cell Trajectories at Single Cell Resolution. Cell Stem Cell, 20, 817-830. http://www.cell.com/cell-stem-cell/fulltext/S1934-5909(17)30127-3


Slingshot: Cell lineage and pseudotime inference for single-cell transcriptomics

bioRxiv, April 2017

Stable and accurate inference of branching trajectories is an important problem in single-cell genomics. We provide a quantitative comparison of existing methods and introduce a more modular novel method, Slingshot. Read more

Kelly Street, Davide Risso, Russell B. Fletcher, Diya Das, John Ngai, Nir Yosef, Elizabeth Purdom, Sandrine Dudoit. (2017). Slingshot: Cell lineage and pseudotime inference for single-cell transcriptomics. bioRxiv 128843. https://doi.org/10.1101/128843