Levi Gadye*, Diya Das*, Michael A. Sanchez*, Kelly Street, Davide Risso, Ariane Baudhuin, Michael B. Cole, Allon Wagner, Yoon Gi Choi, Elizabeth Purdom, Sandrine Dudoit, Nir Yosef, John Ngai, and Russell B. Fletcher*. (2017). Injury Activates Transient Olfactory Stem Cell States With Diverse Lineage Capacities. Cell Stem Cell 21, 775-790.e9.
We use multiple single-cell techniques to identify the cell state transitions underlying the stem cell self- renewal and differentiation during injury- induced regeneration of the olfactory epithelium. Olfactory stem cells shift en masse to a transient cell state unique to regeneration in which diverse fates are specified. Read more